Silencing hsp25/hsp27 gene expression augments proteasome activity and increases CD8(+) T cell-mediated tumor killing and memory responses

Relatively high expression of Hsp27 in breast and prostate cancer is a predictor of poor clinical outcome. This study elucidates a hitherto unknown mechanism by which Hsp27 regulates proteasome function and modulates tumor-specific T cell responses. Here we demonstrated that short term silencing of...

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Main Authors: Nagaraja, Ganachari M., Kaur, Punit, Neumann, William, Asea, Edwina E., Bausero, María A., Multhoff, Gabriele, Asea, Alexzander
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252476/
https://ncbi.nlm.nih.gov/pubmed/22185976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0121
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