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Silencing hsp25/hsp27 gene expression augments proteasome activity and increases CD8(+) T cell-mediated tumor killing and memory responses
Relatively high expression of Hsp27 in breast and prostate cancer is a predictor of poor clinical outcome. This study elucidates a hitherto unknown mechanism by which Hsp27 regulates proteasome function and modulates tumor-specific T cell responses. Here we demonstrated that short term silencing of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252476/ https://ncbi.nlm.nih.gov/pubmed/22185976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0121 |
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