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Influence of Fed-Fasted State on Intestinal PEPT1 Expression and In Vivo Pharmacokinetics of Glycylsarcosine in Wild-Type and Pept1 Knockout Mice
PURPOSE: To determine if fasting would affect the intestinal expression and in vivo functional activity of PEPT1 as determined after oral dosing of the dipeptide glycylsarcosine (GlySar). METHODS: Systemic exposure and tissue distribution studies were performed in wild-type and Pept1 knockout mice,...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252460/ https://ncbi.nlm.nih.gov/pubmed/21904935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0580-9 |
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