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Effect of Dose Escalation on the In Vivo Oral Absorption and Disposition of Glycylsarcosine in Wild-Type and Pept1 Knockout Mice

This study evaluated the in vivo absorption and disposition of glycylsarcosine (GlySar), after escalating oral doses, in wild-type and peptide transporter 1 (Pept1) knockout mice. [(3)H]GlySar was administered to mice at doses of 1, 10, 100, 1000, and 5000 nmol/g b.wt. Serial blood samples were obta...

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Bibliografiske detaljer
Main Authors: Jappar, Dilara, Hu, Yongjun, Smith, David E.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226376/
https://ncbi.nlm.nih.gov/pubmed/21880829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.041087
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