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A METAL SWITCH FOR CONTROLLING THE ACTIVITY OF MOLECULAR MOTOR PROTEINS

Kinesins are molecular motors that require a divalent metal ion (e.g., Mg(2+)) to convert the energy of ATP hydrolysis into directed force production along microtubules. Here we present the crystal structure of a recombinant kinesin motor domain bound to Mn(2+) and ADP, and report on a serine to cys...

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Detalhes bibliográficos
Main Authors: Cochran, Jared C., Zhao, Yu Cheng, Wilcox, Dean E., Kull, F. Jon
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252401/
https://ncbi.nlm.nih.gov/pubmed/22198464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2190
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