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Force generation by kinesin and myosin cytoskeletal motor proteins

Kinesins and myosins hydrolyze ATP, producing force that drives spindle assembly, vesicle transport and muscle contraction. How do motors do this? Here we discuss mechanisms of motor force transduction, based on their mechanochemical cycles and conformational changes observed in crystal structures....

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Bibliographic Details
Main Authors: Kull, F. Jon, Endow, Sharyn A.
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3603507/
https://ncbi.nlm.nih.gov/pubmed/23487037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.103911
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