Transgenic overexpression of bone morphogenetic protein 11 propeptide in skeleton enhances bone formation

Bone morphogenetic protein 11 (BMP11) is a key regulatory protein in skeletal development. BMP11 propeptide has been shown to antagonize GDF11 activity in vitro. To explore the role of BMP11 propeptide in skeletal formation in vivo, we generated transgenic mice with skeleton-specific overexpression...

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Hlavní autoři: Li, Zicong, Zeng, Fang, Mitchell, Alva, Kim, Yong Soo, Wu, Zhenfang, Yang, Jinzeng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252393/
https://ncbi.nlm.nih.gov/pubmed/22093826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.11.019
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