Genome-Wide Analyses of Nkx2-1 Binding to Transcriptional Target Genes Uncover Novel Regulatory Patterns Conserved in Lung Development and Tumors

The homeodomain transcription factor Nkx2-1 is essential for normal lung development and homeostasis. In lung tumors, it is considered a lineage survival oncogene and prognostic factor depending on its expression levels. The target genes directly bound by Nkx2-1, that could be the primary effectors...

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Main Authors: Tagne, Jean-Bosco, Gupta, Sumeet, Gower, Adam C., Shen, Steven S., Varma, Saaket, Lakshminarayanan, Meenakshi, Cao, Yuxia, Spira, Avrum, Volkert, Thomas L., Ramirez, Maria I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252372/
https://ncbi.nlm.nih.gov/pubmed/22242187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029907
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