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SIRT1 associates with eIF2-alpha and regulates the cellular stress response
SIRT1 is a NAD+ dependent protein deacetylase known to increase longevity in model organisms. SIRT1 regulates cellular response to oxidative and/or genotoxic stress by regulating proteins such as p53 and FOXO. The eukaryotic initiation factor-2, eIF2, plays a critical role in the integrated stress r...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252071/ https://ncbi.nlm.nih.gov/pubmed/22355666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00150 |
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