Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo

BACKGROUND: Hyaluronan (HA) plays crucial roles in the tumourigenicity of many types of malignant tumours. 4-Methylumbelliferone (MU) is an inhibitor of HA synthesis. Several studies have shown its inhibitory effects on malignant tumours; however, none have focused on its effects on osteosarcoma. ME...

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Главные авторы: Arai, E, Nishida, Y, Wasa, J, Urakawa, H, Zhuo, L, Kimata, K, Kozawa, E, Futamura, N, Ishiguro, N
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2011
Предметы:
Translational Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251882/
https://ncbi.nlm.nih.gov/pubmed/22045192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.459
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