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Metabolism of Oxycodone in Human Hepatocytes from Different Age Groups and Prediction of Hepatic Plasma Clearance

Oxycodone is commonly used to treat severe pain in adults and children. It is extensively metabolized in the liver in adults, but the maturation of metabolism is not well understood. Our aim was to study the metabolism of oxycodone in cryopreserved human hepatocytes from different age groups (3 days...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Korjamo, Timo, Tolonen, Ari, Ranta, Veli-Pekka, Turpeinen, Miia, Kokki, Hannu
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Frontiers Research Foundation 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251796/
https://ncbi.nlm.nih.gov/pubmed/22291644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2011.00087
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