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In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line

BACKGROUND: In the search for anticancer agents, a promising 17-β-estradiol metabolite, 2-methoxyestradiol (2ME2) was found that exerts antiproliferative in vitro and in vivo activity. Since 2ME2 has limited biological accessibility and rapid metabolic degradation, the purpose of this study was to i...

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Bibliografiske detaljer
Main Authors: Visagie, Michelle H, Joubert, Anna M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251537/
https://ncbi.nlm.nih.gov/pubmed/22152028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-11-43
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