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In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line

BACKGROUND: In the search for anticancer agents, a promising 17-β-estradiol metabolite, 2-methoxyestradiol (2ME2) was found that exerts antiproliferative in vitro and in vivo activity. Since 2ME2 has limited biological accessibility and rapid metabolic degradation, the purpose of this study was to i...

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Autors principals: Visagie, Michelle H, Joubert, Anna M
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251537/
https://ncbi.nlm.nih.gov/pubmed/22152028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-11-43
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