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Incorporation of the Rpn12 Subunit Couples Completion of Proteasome Regulatory Particle Lid Assembly to Lid-Base Joining

The 26S proteasome, the central eukaryotic protease, comprises a core particle capped by a 19S regulatory particle (RP). The RP is divisible into base and lid subcomplexes. Lid biogenesis and incorporation into the RP remain poorly understood. We report several lid intermediates, including the free...

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Detalhes bibliográficos
Main Authors: Tomko, Robert J., Hochstrasser, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251515/
https://ncbi.nlm.nih.gov/pubmed/22195964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.11.020
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