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The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro

In Saccharomyces cerevisiae, a Cdc13–Est1 interaction is proposed to mediate recruitment of telomerase to DNA ends. Here we provide unique in vitro evidence for this model by demonstrating a direct interaction between purified Cdc13 and Est1. The Cdc13–Est1 interaction is specific and requires the i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wu, Yun, Zakian, Virginia A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251085/
https://ncbi.nlm.nih.gov/pubmed/21969561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100281108
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