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Small Molecule Positive Allosteric Modulation of TRPV1 Activation by Vanilloids and Acidic pH

Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a high-conductance, nonselective cation channel strongly expressed in nociceptive primary afferent neurons of the peripheral nervous system and functions as a multimodal nociceptor gated by temperatures greater than 43°C, pr...

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Detalhes bibliográficos
Main Authors: Kaszas, Krisztian, Keller, Jason M., Coddou, Claudio, Mishra, Santosh K., Hoon, Mark A., Stojilkovic, Stanko, Jacobson, Kenneth A., Iadarola, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251023/
https://ncbi.nlm.nih.gov/pubmed/22005042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.183053
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