The Role of Gln(61) in HRas GTP Hydrolysis: A Quantum Mechanics/Molecular Mechanics Study

Activation of the water molecule involved in GTP hydrolysis within the HRas⋅RasGAP system is analyzed using a tailored approach based on hybrid quantum mechanics/molecular mechanics (QM/MM) simulation. A new path emerges: transfer of a proton from the attacking water molecule to a second water molec...

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Main Authors: Martín-García, Fernando, Mendieta-Moreno, Jesús Ignacio, López-Viñas, Eduardo, Gómez-Puertas, Paulino, Mendieta, Jesús
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Biophysical Society 2012
Ábhair:
Protein
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250681/
https://ncbi.nlm.nih.gov/pubmed/22225809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.11.4005
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