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Deep Evolutionary Conservation of an Intramolecular Protein Kinase Activation Mechanism
DYRK-family kinases employ an intramolecular mechanism to autophosphorylate a critical tyrosine residue in the activation loop. Once phosphorylated, DYRKs lose tyrosine kinase activity and function as serine/threonine kinases. DYRKs have been characterized in organisms from yeast to human; however,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3250476/ https://ncbi.nlm.nih.gov/pubmed/22235329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029702 |
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