Deep Evolutionary Conservation of an Intramolecular Protein Kinase Activation Mechanism

DYRK-family kinases employ an intramolecular mechanism to autophosphorylate a critical tyrosine residue in the activation loop. Once phosphorylated, DYRKs lose tyrosine kinase activity and function as serine/threonine kinases. DYRKs have been characterized in organisms from yeast to human; however,...

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Main Authors: Han, Jingfen, Miranda-Saavedra, Diego, Luebbering, Nathan, Singh, Aman, Sibbet, Gary, Ferguson, Michael A. J., Cleghon, Vaughn
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250476/
https://ncbi.nlm.nih.gov/pubmed/22235329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029702
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