Genomic HIV RNA Induces Innate Immune Responses through RIG-I-Dependent Sensing of Secondary-Structured RNA

BACKGROUND: Innate immune responses have recently been appreciated to play an important role in the pathogenesis of HIV infection. Whereas inadequate innate immune sensing of HIV during acute infection may contribute to failure to control and eradicate infection, persistent inflammatory responses la...

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Main Authors: Berg, Randi K., Melchjorsen, Jesper, Rintahaka, Johanna, Diget, Elisabeth, Søby, Stine, Horan, Kristy A., Gorelick, Robert J., Matikainen, Sampsa, Larsen, Carsten S., Ostergaard, Lars, Paludan, Søren R., Mogensen, Trine H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250430/
https://ncbi.nlm.nih.gov/pubmed/22235281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029291
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