FcγRIIIa Expression on Monocytes in Rheumatoid Arthritis: Role in Immune-Complex Stimulated TNF Production and Non-Response to Methotrexate Therapy

OBJECTIVE: The expression of FcγRIIIa/CD16 may render monocytes targets for activation by IgG-containing immune complexes (IC). We investigated whether FcγRIIIa/CD16 was upregulated in rheumatoid arthritis (RA), associated with TNF production in response to IC-stimulation, and if this predicted resp...

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Bibliographic Details
Main Authors: Cooper, Dawn L., Martin, Stephen G., Robinson, James I., Mackie, Sarah L., Charles, Christopher J., Nam, Jackie, Consortium, YEAR, Isaacs, John D., Emery, Paul, Morgan, Ann W.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250404/
https://ncbi.nlm.nih.gov/pubmed/22235253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028918
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