Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β

The K(+) channel KCa3.1 is required for Ca(2+) influx and the subsequent activation of CD4 T cells. The class II phosphatidylinositol 3 kinase C2β (PI3KC2β) is activated by the T-cell receptor (TCR) and is critical for KCa3.1 channel activation. Tripartite motif containing protein 27 (TRIM27) is a m...

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Main Authors: Cai, Xinjiang, Srivastava, Shekhar, Sun, Yi, Li, Zhai, Wu, Haiyan, Zuvela-Jelaska, Ljiljana, Li, Jun, Salamon, Rachel S., Backer, Jonathan M., Skolnik, Edward Y.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2011
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250182/
https://ncbi.nlm.nih.gov/pubmed/22128329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111233109
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