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Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range

Although the proteins comprising many signaling systems are known, less is known about their numbers per cell. Existing measurements often vary by more than 10-fold. Here, we devised improved quantification methods to measure protein abundances in the Saccharomyces cerevisiae pheromone response path...

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Autors principals: Thomson, Ty M., Benjamin, Kirsten R., Bush, Alan, Love, Tonya, Pincus, David, Resnekov, Orna, Yu, Richard C., Gordon, Andrew, Colman-Lerner, Alejandro, Endy, Drew, Brent, Roger
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250143/
https://ncbi.nlm.nih.gov/pubmed/22114196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004042108
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