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A High-Fat Diet Induces Bone Loss in Mice Lacking the Alox5 Gene

5-Lipoxygenase catalyzes leukotriene generation from arachidonic acid. The gene that encodes 5-lipoxygenase, Alox5, has been identified in genome-wide association and mouse Quantitative Trait Locus studies as a candidate gene for obesity and low bone mass. Thus, we tested the hypothesis that Alox5(−...

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Autors principals: Le, Phuong, Kawai, Masanobu, Bornstein, Sheila, DeMambro, Victoria E., Horowitz, Mark C., Rosen, Clifford J.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249675/
https://ncbi.nlm.nih.gov/pubmed/22128029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-0082
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