The relationship between clinical pharmacokinetics of aripiprazole and CYP2D6 genetic polymorphism: effects of CYP enzyme inhibition by coadministration of paroxetine or fluvoxamine

PURPOSE: To investigate the effects of coadministration of paroxetine or fluvoxamine on the pharmacokinetics of aripiprazole in healthy adult Japanese with different CYP2D6 genotypes. METHODS: Fourteen CYP2D6 extensive metabolizer (EM) and 14 CYP2D6 intermediate metabolizer (IM) subjects were coadmi...

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Detalhes bibliográficos
Main Authors: Azuma, Junichi, Hasunuma, Tomoko, Kubo, Masanori, Miyatake, Masaya, Koue, Toshiko, Higashi, Koushi, Fujiwara, Tsutomu, Kitahara, Sachiko, Katano, Tamiki, Hara, Sumiko
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2011
Assuntos:
Clinical Trial
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249179/
https://ncbi.nlm.nih.gov/pubmed/21739267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-011-1094-4
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