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Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

In sporadic Alzheimer’s disease (AD), neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. To identify the modification signature associated with tau lesion formation at single amino acid resolution, immunopurified paire...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Thomas, Stefani N., Funk, Kristen E., Wan, Yunhu, Liao, Zhongping, Davies, Peter, Kuret, Jeff, Yang, Austin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249157/
https://ncbi.nlm.nih.gov/pubmed/22033876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-011-0893-0
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