HIV-1 Vpu Protein Antagonizes Innate Restriction Factor BST-2 via Lipid-embedded Helix-Helix Interactions

The Vpu protein of HIV-1 antagonizes BST-2 (tetherin), a broad spectrum effector of the innate immune response to viral infection, by an intermolecular interaction that maps genetically to the α-helical transmembrane domains (TMDs) of each protein. Here we utilize NMR spectroscopy to describe key fe...

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Bibliografiska uppgifter
Huvudupphovsmän: Skasko, Mark, Wang, Yan, Tian, Ye, Tokarev, Andrey, Munguia, Jason, Ruiz, Autumn, Stephens, Edward B., Opella, Stanley J., Guatelli, John
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Membrane Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249111/
https://ncbi.nlm.nih.gov/pubmed/22072710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.296772
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