BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action

Recent evidence suggests that transmembrane domain (TMD) interactions are essential for HIV-1 Vpu-mediated antagonism of the restriction factor BST-2/tetherin. We made Vpu TMD mutants to study the mechanism of BST-2 antagonism. Vpu-I17A, -A18F, - W22L, and -S23L co-localized with BST-2 within endoso...

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Detaylı Bibliyografya
Asıl Yazarlar: Skasko, Mark, Tokarev, Andrey, Chen, Cheng-Chang, Fischer, Wolfgang B., Pillai, Satish K., Guatelli, John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086044/
https://ncbi.nlm.nih.gov/pubmed/21237475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.12.038
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