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Multiple SecA Molecules Drive Protein Translocation across a Single Translocon with SecG Inversion

SecA is a translocation ATPase that drives protein translocation. D209N SecA, a dominant-negative mutant, binds ATP but is unable to hydrolyze it. This mutant was inactive to proOmpA translocation. However, it generated a translocation intermediate of 18 kDa. Further addition of wild-type SecA cause...

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Detalhes bibliográficos
Main Authors: Morita, Kazuhiro, Tokuda, Hajime, Nishiyama, Ken-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249098/
https://ncbi.nlm.nih.gov/pubmed/22074917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.301754
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