Structure-guided Engineering of Human Thymidine Kinase 2 as a Positron Emission Tomography Reporter Gene for Enhanced Phosphorylation of Non-natural Thymidine Analog Reporter Probe

Positron emission tomography (PET) reporter gene imaging can be used to non-invasively monitor cell-based therapies. Therapeutic cells engineered to express a PET reporter gene (PRG) specifically accumulate a PET reporter probe (PRP) and can be detected by PET imaging. Expanding the utility of this...

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Autori principali: Campbell, Dean O., Yaghoubi, Shahriar S., Su, Ying, Lee, Jason T., Auerbach, Martin S., Herschman, Harvey, Satyamurthy, Nagichettiar, Czernin, Johannes, Lavie, Arnon, Radu, Caius G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Protein Structure and Folding
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249097/
https://ncbi.nlm.nih.gov/pubmed/22074768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.314666
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