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Nicorandil prevents endothelial dysfunction due to antioxidative effects via normalisation of NADPH oxidase and nitric oxide synthase in streptozotocin diabetic rats

BACKGROUND: Nicorandil, an anti-angina agent, reportedly improves outcomes even in angina patients with diabetes. However, the precise mechanism underlying the beneficial effect of nicorandil on diabetic patients has not been examined. We investigated the protective effect of nicorandil on endotheli...

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Detalhes bibliográficos
Main Authors: Serizawa, Ken-ichi, Yogo, Kenji, Aizawa, Ken, Tashiro, Yoshihito, Ishizuka, Nobuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248842/
https://ncbi.nlm.nih.gov/pubmed/22107602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2840-10-105
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