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Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility

The identification of the factors that enable normally folded proteins to remain in their soluble and functional states is crucial for a comprehensive understanding of any biological system. We have determined a series of energy landscapes of the acylphosphatase from Drosophila melanogaster under a...

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Detalhes bibliográficos
Main Authors: De Simone, Alfonso, Dhulesia, Anne, Soldi, Gemma, Vendruscolo, Michele, Hsu, Shang-Te Danny, Chiti, Fabrizio, Dobson, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248487/
https://ncbi.nlm.nih.gov/pubmed/22160682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112197108
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