Triple Combination Antiviral Drug (TCAD) Composed of Amantadine, Oseltamivir, and Ribavirin Impedes the Selection of Drug-Resistant Influenza A Virus

Widespread resistance among circulating influenza A strains to at least one of the anti-influenza drugs is a major public health concern. A triple combination antiviral drug (TCAD) regimen comprised of amantadine, oseltamivir, and ribavirin has been shown to have synergistic and broad spectrum activ...

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Bibliographic Details
Main Authors: Hoopes, Justin D., Driebe, Elizabeth M., Kelley, Erin, Engelthaler, David M., Keim, Paul S., Perelson, Alan S., Rong, Libin, Went, Gregory T., Nguyen, Jack T.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248427/
https://ncbi.nlm.nih.gov/pubmed/22220216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029778
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