Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial Homeostasis

BACKGROUND: Altered dosage of the transcription factor PAX6 causes multiple human eye pathophysiologies. PAX6 (+/−) heterozygotes suffer from aniridia and aniridia-related keratopathy (ARK), a corneal deterioration that probably involves a limbal epithelial stem cell (LESC) deficiency. Heterozygous...

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Main Authors: Mort, Richard L., Bentley, Adam J., Martin, Francis L., Collinson, J. Martin, Douvaras, Panagiotis, Hill, Robert E., Morley, Steven D., Fullwood, Nigel J., West, John D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248408/
https://ncbi.nlm.nih.gov/pubmed/22220198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028895
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