MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop

Constitutive activation of NF-κB is a frequent event in human cancers, playing important roles in cancer development and progression. In nontransformed cells, NF-κB activation is tightly controlled by IκBs. IκBs bind NF-κB in the cytoplasm, preventing it from translocating to the nucleus to modulate...

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Main Authors: Jiang, Lili, Lin, Chuyong, Song, Libing, Wu, Jueheng, Chen, Baixue, Ying, Zhe, Fang, Lishan, Yan, Xiao, He, Mian, Li, Jun, Li, Mengfeng
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248293/
https://ncbi.nlm.nih.gov/pubmed/22156201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58849
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