Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

Epoxyeicosatrienoic acids (EETs) are small molecules produced by cytochrome P450 epoxygenases. They are lipid mediators that act as autocrine or paracrine factors to regulate inflammation and vascular tone. As a result, drugs that raise EET levels are in clinical trials for the treatment of hyperten...

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Autors principals: Panigrahy, Dipak, Edin, Matthew L., Lee, Craig R., Huang, Sui, Bielenberg, Diane R., Butterfield, Catherine E., Barnés, Carmen M., Mammoto, Akiko, Mammoto, Tadanori, Luria, Ayala, Benny, Ofra, Chaponis, Deviney M., Dudley, Andrew C., Greene, Emily R., Vergilio, Jo-Anne, Pietramaggiori, Giorgio, Scherer-Pietramaggiori, Sandra S., Short, Sarah M., Seth, Meetu, Lih, Fred B., Tomer, Kenneth B., Yang, Jun, Schwendener, Reto A., Hammock, Bruce D., Falck, John R., Manthati, Vijaya L., Ingber, Donald E., Kaipainen, Arja, D’Amore, Patricia A., Kieran, Mark W., Zeldin, Darryl C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248288/
https://ncbi.nlm.nih.gov/pubmed/22182838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58128
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