Lowered Expression of Heparan Sulfate/Heparin Biosynthesis Enzyme N-Deacetylase/N-Sulfotransferase 1 Results in Increased Sulfation of Mast Cell Heparin

Deficiency of the heparan sulfate biosynthesis enzyme N-deacetylase/N-sulfotransferase 1 (NDST1) in mice causes severely disturbed heparan sulfate biosynthesis in all organs, whereas lack of NDST2 only affects heparin biosynthesis in mast cells (MCs). To investigate the individual and combined roles...

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Bibliographische Detailangaben
Hauptverfasser: Dagälv, Anders, Holmborn, Katarina, Kjellén, Lena, Åbrink, Magnus
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248000/
https://ncbi.nlm.nih.gov/pubmed/22049073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.303891
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