Connexin-43 Hemichannels Mediate Cyclic ADP-ribose Generation and Its Ca(2+)-mobilizing Activity by NAD(+)/Cyclic ADP-ribose Transport

The ADP-ribosyl cyclase CD38 whose catalytic domain resides in outside of the cell surface produces the second messenger cyclic ADP-ribose (cADPR) from NAD(+). cADPR increases intracellular Ca(2+) through the intracellular ryanodine receptor/Ca(2+) release channel (RyR). It has been known that intra...

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Main Authors: Song, Eun-Kyung, Rah, So-Young, Lee, Young-Rae, Yoo, Chae-Hwa, Kim, Yu-Ri, Yeom, Ji-Hyun, Park, Kwang-Hyun, Kim, Jong-Suk, Kim, Uh-Hyun, Han, Myung-Kwan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247979/
https://ncbi.nlm.nih.gov/pubmed/22033928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.307645
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