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Subunit and Domain Requirements for Adenylate-mediated Protection of Snf1 Kinase Activation Loop from Dephosphorylation

Members of the AMP-activated protein kinase (AMPK) family are activated by phosphorylation at a conserved threonine residue in the activation loop of the kinase domain. Mammalian AMPK adopts a phosphatase-resistant conformation that is stabilized by binding low energy adenylate molecules. Similarly,...

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Autors principals: Chandrashekarappa, Dakshayini G., McCartney, Rhonda R., Schmidt, Martin C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247968/
https://ncbi.nlm.nih.gov/pubmed/22065577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.315895
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