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Subunit and Domain Requirements for Adenylate-mediated Protection of Snf1 Kinase Activation Loop from Dephosphorylation
Members of the AMP-activated protein kinase (AMPK) family are activated by phosphorylation at a conserved threonine residue in the activation loop of the kinase domain. Mammalian AMPK adopts a phosphatase-resistant conformation that is stabilized by binding low energy adenylate molecules. Similarly,...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3247968/ https://ncbi.nlm.nih.gov/pubmed/22065577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.315895 |
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