Human native lipoprotein-induced de novo DNA methylation is associated with repression of inflammatory genes in THP-1 macrophages

BACKGROUND: We previously showed that a VLDL- and LDL-rich mix of human native lipoproteins induces a set of repressive epigenetic marks, i.e. de novo DNA methylation, histone 4 hypoacetylation and histone 4 lysine 20 (H4K20) hypermethylation in THP-1 macrophages. Here, we: 1) ask what gene expressi...

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Detalhes bibliográficos
Main Authors: Rangel-Salazar, Rubén, Wickström-Lindholm, Marie, Aguilar-Salinas, Carlos A, Alvarado-Caudillo, Yolanda, Døssing, Kristina BV, Esteller, Manel, Labourier, Emmanuel, Lund, Gertrud, Nielsen, Finn C, Rodríguez-Ríos, Dalia, Solís-Martínez, Martha O, Wrobel, Katarzyna, Wrobel, Kazimierz, Zaina, Silvio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247910/
https://ncbi.nlm.nih.gov/pubmed/22118513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-12-582
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