Progenitor expansion in apc mutants is mediated by Jak/Stat signaling

BACKGROUND: Mutations in APC, a negative regulator of the Wnt/ß-catenin pathway, can cause cancer as well as profound developmental defects. In both cases, affected cells adopt a proliferative progenitor state and fail to differentiate. While the upregulation of some target genes of Wnt/ß-catenin si...

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Bibliographic Details
Main Authors: Lin, Junji, Wang, Xu, Dorsky, Richard I
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247185/
https://ncbi.nlm.nih.gov/pubmed/22136118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-11-73
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