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Progenitor expansion in apc mutants is mediated by Jak/Stat signaling
BACKGROUND: Mutations in APC, a negative regulator of the Wnt/ß-catenin pathway, can cause cancer as well as profound developmental defects. In both cases, affected cells adopt a proliferative progenitor state and fail to differentiate. While the upregulation of some target genes of Wnt/ß-catenin si...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BioMed Central
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3247185/ https://ncbi.nlm.nih.gov/pubmed/22136118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-11-73 |
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