FragSeq: transcriptome-wide RNA structure probing using high-throughput sequencing

Previous efforts to determine structures of non-coding RNA (ncRNA) probed only one RNA at a time with enzymes and chemicals, using gel electrophoresis to identify reactive positions. To accelerate RNA structure inference, we have developed FragSeq, a high-throughput RNA structure probing method that...

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Main Authors: Underwood, Jason G., Uzilov, Andrew V., Katzman, Sol, Onodera, Courtney S., Mainzer, Jacob E., Mathews, David H., Lowe, Todd M., Salama, Sofie R., Haussler, David
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3247016/
https://ncbi.nlm.nih.gov/pubmed/21057495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1529
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