Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

E-cadherin (CDH1) loss occurs frequently in carcinogenesis, contributing to invasion and metastasis. We observed that mouse and human epithelial cell lines overexpressing the replication licensing factor Cdc6 underwent phenotypic changes with mesenchymal features and loss of E-cadherin. Analysis in...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Sideridou, Maria, Zakopoulou, Roubini, Evangelou, Konstantinos, Liontos, Michalis, Kotsinas, Athanassios, Rampakakis, Emmanouil, Gagos, Sarantis, Kahata, Kaoru, Grabusic, Kristina, Gkouskou, Kalliopi, Trougakos, Ioannis P., Kolettas, Evangelos, Georgakilas, Alexandros G., Volarevic, Sinisa, Eliopoulos, Aristides G., Zannis-Hadjopoulos, Maria, Moustakas, Aristidis, Gorgoulis, Vassilis G.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2011
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246883/
https://ncbi.nlm.nih.gov/pubmed/22201124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201108121
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia