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Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins
E-cadherin (CDH1) loss occurs frequently in carcinogenesis, contributing to invasion and metastasis. We observed that mouse and human epithelial cell lines overexpressing the replication licensing factor Cdc6 underwent phenotypic changes with mesenchymal features and loss of E-cadherin. Analysis in...
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| Huvudupphovsmän: | , , , , , , , , , , , , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
The Rockefeller University Press
2011
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3246883/ https://ncbi.nlm.nih.gov/pubmed/22201124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201108121 |
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