Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

E-cadherin (CDH1) loss occurs frequently in carcinogenesis, contributing to invasion and metastasis. We observed that mouse and human epithelial cell lines overexpressing the replication licensing factor Cdc6 underwent phenotypic changes with mesenchymal features and loss of E-cadherin. Analysis in...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Sideridou, Maria, Zakopoulou, Roubini, Evangelou, Konstantinos, Liontos, Michalis, Kotsinas, Athanassios, Rampakakis, Emmanouil, Gagos, Sarantis, Kahata, Kaoru, Grabusic, Kristina, Gkouskou, Kalliopi, Trougakos, Ioannis P., Kolettas, Evangelos, Georgakilas, Alexandros G., Volarevic, Sinisa, Eliopoulos, Aristides G., Zannis-Hadjopoulos, Maria, Moustakas, Aristidis, Gorgoulis, Vassilis G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2011
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246883/
https://ncbi.nlm.nih.gov/pubmed/22201124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201108121
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk