ENU Mutagenesis Screen to Establish Motor Phenotypes in Wild-Type Mice and Modifiers of a Pre-Existing Motor Phenotype in Tau Mutant Mice

Modifier screening is a powerful genetic tool. While not widely used in the vertebrate system, we applied these tools to transgenic mouse strains that recapitulate key aspects of Alzheimer's disease (AD), such as tau-expressing mice. These are characterized by a robust pathology including both...

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Detalles Bibliográficos
Main Authors: Liu, Xin, Dobbie, Michael, Tunningley, Rob, Whittle, Belinda, Zhang, Yafei, Ittner, Lars M., Götz, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2011
Assuntos:
Methodology Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246812/
https://ncbi.nlm.nih.gov/pubmed/22219655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/130947
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