Genotype–Phenotype Map Characteristics of an In silico Heart Cell

Understanding the causal chain from genotypic to phenotypic variation is a tremendous challenge with huge implications for personalized medicine. Here we argue that linking computational physiology to genetic concepts, methodology, and data provides a new framework for this endeavor. We exemplify th...

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Detalhes bibliográficos
Main Authors: Vik, Jon Olav, Gjuvsland, Arne B., Li, Liren, Tøndel, Kristin, Niederer, Steven, Smith, Nicolas P., Hunter, Peter J., Omholt, Stig W.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2011
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246639/
https://ncbi.nlm.nih.gov/pubmed/22232604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2011.00106
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