Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

Sclerostin, the Wnt signaling antagonist encoded by the Sost gene, is secreted by osteocytes and inhibits bone formation by osteoblasts. Mechanical stimulation reduces sclerostin expression, suggesting that osteocytes might coordinate the osteogenic response to mechanical force by locally unleashing...

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Autori principali: Tu, Xiaolin, Rhee, Yumie, Condon, Keith, Bivi, Nicoletta, Allen, Matthew R., Dwyer, Denise, Stolina, Marina, Turner, Charles H., Robling, Alexander G., Plotkin, Lilian I., Bellido, Teresita
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246572/
https://ncbi.nlm.nih.gov/pubmed/22075208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2011.10.025
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