Natural Product Libraries to Accelerate the High Throughput Discovery of Therapeutic Leads±

A high throughput (HT) paradigm generating LC-MS-UV-ELSD based natural product libraries to discover compounds with new bioactivities and or molecular structures is presented. To validate this methodology an extract of the Indo Pacific marine sponge Cacospongia mycofijiensis was evaluated using assa...

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Autori principali: Johnson, Tyler A., Sohn, Johann, Inman, Wayne D., Estee, Samarkand A., Loveridge, Steven T., Vervoort, Helene C., Tenney, Karen, Liu, Junke, Ang, Kenny Kean-Hooi, Ratnam, Joseline, Bray, Walter M., Gassner, Nadine C., Shen, Young Y., Lokey, R. Scott, McKerrow, James H., Boundy-Mills, Kyria, Nukanto, Arif, Kanti, Atit, Julistiono, Heddy, Kardono, Leonardus B. S., Bjeldanes, Leonard F., Crews, Phillip
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246535/
https://ncbi.nlm.nih.gov/pubmed/22129061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np200673b
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