Natural Product Libraries to Accelerate the High Throughput Discovery of Therapeutic Leads±

A high throughput (HT) paradigm generating LC-MS-UV-ELSD based natural product libraries to discover compounds with new bioactivities and or molecular structures is presented. To validate this methodology an extract of the Indo Pacific marine sponge Cacospongia mycofijiensis was evaluated using assa...

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Autors principals: Johnson, Tyler A., Sohn, Johann, Inman, Wayne D., Estee, Samarkand A., Loveridge, Steven T., Vervoort, Helene C., Tenney, Karen, Liu, Junke, Ang, Kenny Kean-Hooi, Ratnam, Joseline, Bray, Walter M., Gassner, Nadine C., Shen, Young Y., Lokey, R. Scott, McKerrow, James H., Boundy-Mills, Kyria, Nukanto, Arif, Kanti, Atit, Julistiono, Heddy, Kardono, Leonardus B. S., Bjeldanes, Leonard F., Crews, Phillip
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246535/
https://ncbi.nlm.nih.gov/pubmed/22129061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np200673b
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